North American Pharmacist Licensure Examination (NAPLEX) Free Practice Test

Question 1

You receive an order for 40mg/kg/dose of Amoxicillin every 12 hours. Pt's weight is 18 lbs. You have
250mg/5ml of amoxicillin suspension.
Calculate the total amount in milliliters needed for 10-day supply. Round up your answer to the nearest 1.

A. 14 mls

B. 96 mls

C. 132 mls

D. 36 mls

E. 86 mls

Correct Answer: C

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Question 2

Injectable Sulfamethoxazole/Trimethoprim comes as 400mg/80mg/5ml. Physician requests you to dose a Sulfamethoxazole/Trimethoprim intravenously for PCP. You know the dose is 15mg/kg/day (based on TMP component) divided q6h.
How many milliliters of Sulfamethoxazole/Trimethoprim of 400mg/80mg/5ml would you need for single dose? Patient weighs 80kg.

A. 50 mL

B. 16.5 mL

C. 18.75 mL

D. 15 mL

E. 75 mL

Correct Answer: C

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Question 3

A physician needs your help to calculate the protamine dose on a patient who started hemorrhaging while on heparin. Patient has been receiving heparin at a dose of 13mls/hr for 2 hrs when the physician decides to use protamine to reverse the heparin. Heparin bag says concentration of 50 units/ml. The half-life of heparin is 60 minutes. 1 mg of protamine reverses 100 units of heparin.
How much protamine should be given to this patient?

A. 13mg

B. 7mg

C. 10mg

D. 9.7mg

E. 5mg

Correct Answer: D

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Question 4

Which of the following is considered first-line therapy for reducing the risk of atherosclerotic cardiovascular disease (ASCVD)?

A. Nicotinic Acid

B. Fish oil

C. Fibrates

D. Bile acid resins

E. HMG Co-A reductase inhibitors

Correct Answer: E

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Question 5

What is the best anti-thyroid regimen in a pregnant woman who has clinically significant hyperthyroidism?

A. Propylthiouracil

B. Propylthiouracil first trimester followed by methimazole for the remainder of pregnancy

C. Stop treatment and resume post-partum

D. Methimazole first trimester followed by propylthiouracil for the remainder of pregnancy

E. Methimazole

Correct Answer: B

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Question 6

What is the weight of 1000 ml of serum protein whose specific gravity is 1.27?

A. 1270 gm

B. 1.27gm

C. 12.7mg

D. 127mg

E. 12.7gm

Correct Answer: A

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Question 7

LT is a 42-year-old white female with past medical history of epilepsy, gastroesophageal reflux disease and seasonal allergies. She weighs 86 kg, height 5'6" and allergic to Aspirin (rash) and Phenobarbital (difficulty breathing).
Her medications include Omeprazole 40mg daily, Phenytoin 200mg twice daily, Valproic acid 500mg four times daily, Loratadine 10mg daily. She comes to your community pharmacy to pick up prescription for Primidone 250mg twice daily.
Pertaining to Primidone what is the most appropriate action to take?

A. Notify the physician, Primidone in contraindicated in patient with phenobarbital allergy.

B. Notify the physician, Primidone in contraindicated in patient with gastroesophageal reflux disease.

C. Notify the physician, Primidone dose is too low.

D. Notify the physician, Primidone in contraindicated in patient with Aspirin allergy.

E. Notify the physician, patient is already on three anti-seizure medication and primidone is not needed.

Correct Answer: A

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Question 8

Concomitant use of warfarin and omeprazole is associated with increased INR and prothrombin time(PT).
What enzyme dose the omeprazole inhibits that is metabolized by warfarin?

A. CYP2C9

B. CYP2D9

C. CYP3A4

D. CYP1A2

E. CYP2C19

Correct Answer: E

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Question 9

What is the active ingredient found in the medicine Adalat?

A. Simvastatin

B. Adalimumab

C. Digoxin

D. Nifedipine

Correct Answer: D

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Question 10

In Normal distribution, what percentage of the sample is found within 2 standard deviation of the mean?

A. 95%

B. 99%

C. 72%

D. 100%

E. 68%

Correct Answer: A

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Question 11

Which of the following are non-pharmacological measure that may control symptoms of gastroesophageal reflux disease?

A. Discontinue nicotine use in patients that uses tobacco product.

B. Increase fat intake to reduce gastric emptying time Reduce intake of food or beverage that may reduce

C. Wear tight fitted cloths to increase intra-abdominal pressure.

D. Remain upright after a meal

E. lower esophageal sphincter tone

Correct Answer: A

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Question 12

LN is 84 YOM who is in hospital for a back surgery. His height is 5 feet and 4 inches, weight 85 kg and NKDA. His past medical history includes hypertension, diabetes mellitus, major depression, hypothyroidism and chronic back pain.
Post-op day 1, LN's medication includes Dexamethasone 8 mg iv q6h with taper dosing, Ondansetron 4 mg iv q6h prn for N/V, Levothyroxine 0.075 mg po daily, Lisinopril 10 mg po daily, Citalopram 20 mg po daily, Docusate sodium / Senna 1 tab po twice a day, Bisacodyl 10 mg suppository daily prn for constipation, Famotidine 20 mg iv q12hr, Metoclopramide 10 mg iv q6h, Metformin 500 mg po bid, D51/2NS with 20 K at
125 mls/hour and Hydromorphone PCA at 0.2 mg/hour of basal rate, demand dose 0.1 mg. lock-out every 6 min, one hour limit 2.2 mg/hour. Pertinent morning labs includes serum creatinine 1.4 mg/dl, Mg 1.5 mg/dl, K
5.0 mmol/L, Na 135 mmol/L.
Which of the following medication may cause tardive dyskinesia when given at a higher dose and for a long duration?

A. Lisinopril

B. Metoclopramide

C. Famotidine

D. Hydromorphone

E. Dexamethasone

Correct Answer: B

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Question 13

Your patient, a 25-year-old G1P0 female at 26 weeks gestation presents due to an abnormal glucose tolerance test. One week prior, she was given 50 g of oral glucose and demonstrate a venous plasma glucose level of 156 mg/dL one hour later.
Which of the following is the most appropriate next step of management?

A. Begin insulin treatment

B. Repeat the 50 g oral glucose challenge

C. Order a fetal ultrasound examination

D. Advise the patient to follow an American Diabetic Association diet plan

E. Administer an oral, 3-hour 100 g glucose dose

Correct Answer: E

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NABP North American Pharmacist Licensure Examination (NAPLEX) Free Practice Test